Cytotoxic Fatty Acid Amides from Xenorhabdus

Cytotoxic fatty acid amides from Xenorhabdus.

Microsomal synthesis of fatty acid amides.

A microsomal system is described which catalyzes the formation of fatty acid amides of ethanolamine and of several pharmacologically active amines. Although the system has no dependance on external energy sources and has a high K, for the amine substrate, it has several characteristics which differ markedly from an amide hydrolytic system in the microsomes. A possible mechanism for the formatio...

Cytotoxic Fatty Acid Glycerides from the Seeds of Psoralea Corylifolia

The seeds of Psoralea corylifolia Linn. (Fabaceae) have been used extensively as a remedy for leucoderma and Vitiligo. A number of compounds have been isolated from the seeds like furocoumarins, chalcones, flavonoids, terpenoids etc.. We have reported the cytotoxic and antitumour properties of the hexane extract of the seeds of P.corylifolia. The present investigation reports the identification...

Fatty Acid Amides of Ethanolamine in Mammalian Tissues.

While investigating the metabolism of ethanolamine by rat liver microsomes, we observed an incorporation of this amine into microsomal lipid that was dependent on the presence of a fatty acid as cosubstrate (1). It was shown that the product of the enzymatic reaction was the fatty acid amide of ethanolamine and that the reaction was synthetic, since little hydrolysis of added fatty acid amide c...

Identification of fatty acids and fatty acid amides in human meibomian gland secretions.

PURPOSE The complex superficial lipid layer of the tear film functions to prevent evaporation and maintain tear stability. Although classes of lipids found in the tear film have been reported, individual lipid species are currently being studied with more sophisticated. METHODS The purpose of this work was to show the identification of fatty acids and the fatty acid amides in human meibomian ...